(Sentinel Node Following
study, demonstrated many
important points that need
dissemination, such as the
superiority of using both blue
dye and radioactive tracer for
sentinel lymph node biopsy after
chemotherapy in node-positive
4, 5 Z1071, together with
additional work in this area, has
shown that placing a clip in a
lymph node when percutaneous
biopsy is done before
chemotherapy and ensuring
removal of that “clipped”
node after chemotherapy are
useful techniques to improve
the accuracy of sentinel lymph
node surgery in this setting.
of these trials is important to
ensure that trial results are
not applied in circumstances
excluded from the trial or in
populations of patients who
were ineligible for the trial.
Abigail Caudle, MD, FACS, a
breast surgeon at the University
of Texas MD Anderson Cancer
Center, Houston, will kick
off the video pilot project by
creating a video describing
the implementation of Z1071
findings, which is intended
to help local tumor boards
start a discussion on how to
implement these findings
into clinical practice.
We are looking for CoC
sites that would be interested
in participating in the pilot by
having the video presented at
their tumor board and reviewing
the outcomes of the presentation.
If you are interested in
volunteering to use this
video-based educational tool,
contact Amanda Francescatti,
MS, Manager, ACS CRP, at
1. Department of Health and
Human Services. Part 1: Overview
information dissemination and
implementation research in health
(R01). Available at: grants.nih.gov/
html. Accessed April 18, 2017.
2. Giuliano AE, Ballman K, McCall L,
et al. Locoregional recurrence after
sentinel lymph node dissection with
or without axillary dissection in
patients with sentinel lymph node
metastases: Long-term follow-up from
the American College of Surgeons
Oncology Group (Alliance) ACOSOG
Z0011 randomized trial. Ann Surg.
3. Boughey JC, Suman VJ, Mittendorf
EA, et al. Alliance for Clinical
Trials in Oncology. Sentinel lymph
node surgery after neoadjuvant
chemotherapy in patients with node-positive breast cancer: The ACOSOG
Z1071 (Alliance) clinical trial. JAMA.
4. Kuehn T, Bauerfeind I, Fehm T, et
al. Sentinel lymph node biopsy in
patients with breast cancer before
and after neoadjuvant chemotherapy
(SEN TINA): A prospective,
multicenter cohort study. Lancet
Oncol. 2013; 14( 7):609-618.
5. Boileau JF, Poirier B, Basik M,
et al. Sentinel node biopsy after
neoadjuvant chemotherapy in biopsy-proven node-positive breast cancer:
The SN FNAC study. J Clin Oncol.
2015; 33( 3):258-264.
Thoughtful implementation of these trials is
important to ensure that trial results are not applied in
circumstances excluded from the trial or in populations
of patients who were ineligible for the trial.