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REFERENCES (CONTINUED) of beans or legumes per day,
whereas those in the control
group received printed materials
recommending consumption of a
healthy diet. The primary study
outcome is clinical progression,
which is defined as PSA> 10 ng/
mL, PSA doubling time < 3 years,
or increase in tumor volume or
Gleason score. 12 Results from the
study are expected next summer.
The performance of such a
trial serves to fill a considerable
need to quantify the effect of a
well-specified dietary intervention
on PCa progression during active
surveillance. 13 More broadly,
MEAL’s completion is notable for
representing a randomized trial in
low-risk patients, where virtually
no level 1 evidence currently
exists in support of modifying
short-term disease trajectory.
These efforts highlight the breadth
of work on this topic, ranging
from preclinical work addressing
putative mechanisms of disease
prevention to observational studies,
as well as randomized clinical
trials that seek to directly examine
the effect of discrete dietary
and lifestyle interventions. ♦
52 |
ACS CLINICAL RESEARCH PROGRAM
TABLE 2. DEFINITIONS OF THE LIFESTYLE SCORE DERIVED FROM THE HPFS
ON THE OCCURRENCE OF LETHAL PCa9
Factor Definition Points
Smoking status Never smoker or quit ≥ 10 years 1
Body mass index < 30 kg/m2 1
Physical activity ≥ 3 hours/week vigorous activity (≥ 6 METs) and/or ≥ 7 hours/week brisk walking 1
Tomatoes ≥ 7 servings/week raw tomatoes, tomato juice, tomato sauce, salsa, pizza 1
Fatty fish ≥ 1 serving/week mackerel, salmon, sardines, blue-fish, swordfish 1
Processed meat < 3 servings/week of beef or pork hot dogs, bacon, salami, bologna, or other processed meat sandwiches, and other processed meats 1
Total points 6
