(1-877-44U-QUIT). Patients will
be randomized to either placebo
or varenicline, also known as
Chantix (see study schema,
Figure 1, page 59). The study
will evaluate the relationship
between smoking cessation,
and duration of smoking
cessation before surgery.
In this study, surgery
should be performed at least
10 days after randomization
to trials and within 12 weeks
of randomization. The accrual
goal is 626 patients who have
lung cancer surgery and are
followed for 24 weeks after
the operation. The primary
outcome will be the rate of
surgical complications, as
identified using American
College of Surgeons National
Surgical Quality Improvement
Program (ACS NSQIP®) data.
Secondary outcomes include
quality of life, postoperative
care (length of hospital and
high dependency unit stay), and
rates of smoking abstinence. All
patients will have the option
of enrolling in the correlative
genetic study. Alliance
A211401 is now recruiting
participants. Refer to the study
This life-changing information can be a critical teachable
moment, when patients truly internalize the importance of
changing their habits, accelerate their motivation to quit,
and rapidly push themselves through the stages of change.
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